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Production of Vitamin B2 (Riboflavin) by Microorganisms: An Overview
Liudmila A Averianova1, Larissa A Balabanova1,2, Oksana M Son1,3
1Department of Bioeconomy and Food Security, School of Economics and Management, Far Eastern Federal University, Vladivostok, Russia.
Frontiers in Bioengineering and Biotechnology
|December 11, 2020
Summary
This review covers microbial production of riboflavin (vitamin B2), detailing how biotechnology and metabolic engineering enhance yields. It highlights key industrial producers and optimization strategies for increased vitamin B2 output.
Area of Science:
- Biochemistry
- Microbiology
- Biotechnology
Background:
- Riboflavin (vitamin B2) is essential for cellular biochemical reactions and widely used as a nutritional supplement.
- Optimizing riboflavin production is crucial for meeting global demand.
Purpose of the Study:
- To review current research on microbial riboflavin production.
- To summarize advancements in biotechnology and metabolic engineering for increasing vitamin B2 yield.
Main Methods:
- Review of industrial microbial producers: Ashbya gossypii, Bacillus subtilis, and Candida spp.
- Analysis of biosynthetic pathway optimizations.
- Integration of genetic and metabolic engineering with mutagenesis and medium optimization.
Main Results:
- Identification of key microbial strains for industrial riboflavin production.
- Summary of successful genetic and metabolic engineering strategies.
- Demonstration of yield improvements through combined optimization techniques.
Conclusions:
- Biotechnology and metabolic engineering are vital for enhancing riboflavin production.
- Further research into microbial strain improvement is necessary for increased vitamin B2 yield.
Keywords:
food/feed additivegenetically modified microorganismsmetabolic engineeringriboflavinvitamin B2More Related Videos
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