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Eye to the Future in Adenomyosis Research
Lisa M Halvorson1, Linda C Giudice2, Elizabeth A Stewart3
1Gynecologic Health and Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland.
Seminars in Reproductive Medicine
|December 11, 2020
Summary
Adenomyosis research needs improvement. This review highlights future directions in basic, translational, and clinical studies to better understand this gynecologic disorder and its associated symptoms like pelvic pain and heavy bleeding.
Area of Science:
- Gynecology
- Reproductive Medicine
- Pathophysiology
Background:
- Adenomyosis is a poorly understood gynecologic disorder.
- It causes significant morbidity, including dysmenorrhea, pelvic pain, heavy menstrual bleeding, infertility, and adverse pregnancy outcomes.
- Current understanding of adenomyosis is limited across all research aspects.
Purpose of the Study:
- To summarize current knowledge and future research directions in adenomyosis.
- To address gaps in understanding epidemiology, risk factors, pathogenesis, pathophysiology, diagnosis, and treatment.
- To guide future basic, translational, and clinical research endeavors.
Main Methods:
- Literature review and synthesis of current research.
- Identification of knowledge gaps in adenomyosis.
- Discussion of future research priorities.
Main Results:
- Significant gaps exist in understanding adenomyosis.
- Future research is needed in epidemiology, risk factors, pathogenesis, pathophysiology, diagnosis, and treatment.
- A multi-faceted research approach is required.
Conclusions:
- Further research is critical to improve the understanding and management of adenomyosis.
- Future studies should focus on basic science, translational research, and clinical applications.
- Addressing these research gaps will improve patient outcomes and reduce morbidity.
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