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Association Between Plasma ADAMTS-9 Levels and Severity of Coronary Artery Disease
Mengqiu Wei1, Hailin Pan2, Kai Guo3,4
1Intensive Care Unit, Zhongshan People's Hospital, Zhongshan City, Guangdong, China.
Insights
Elevated levels of a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS-9) are linked to coronary artery disease (CAD) and predict worse outcomes in acute myocardial infarction patients.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Genetics
Background:
- Genome-wide association studies suggest a link between ADAMTS-9 and atherosclerosis.
- Coronary artery disease (CAD) poses a significant global health burden.
- Understanding novel biomarkers for CAD diagnosis and prognosis is crucial.
Purpose of the Study:
- To investigate the association of ADAMTS-9 serum levels with the presence, severity, and prognosis of CAD.
- To evaluate ADAMTS-9 as a potential diagnostic and prognostic biomarker for CAD.
Main Methods:
- A cohort of 666 participants undergoing coronary angiography was studied.
- Serum ADAMTS-9 levels were measured and correlated with CAD status, severity (SYNTAX score), and clinical outcomes.
- Statistical analyses included logistic regression and survival analysis.
Main Results:
- Serum ADAMTS-9 levels were significantly higher in CAD patients compared to non-CAD controls (37.53 vs 12.04 ng/mL, P < .001).
- ADAMTS-9 was an independent predictor of CAD (OR = 1.871, P < .001) and correlated with the SYNTAX score (r = 0.523, P < .001).
- Elevated ADAMTS-9 predicted a higher risk of major adverse cardiovascular events (MACE) in acute myocardial infarction patients within 12 months (P = .034).
Conclusions:
- Plasma ADAMTS-9 levels are elevated in patients with coronary artery disease.
- ADAMTS-9 serves as an independent predictor for CAD diagnosis.
- ADAMTS-9 levels are associated with disease severity and can predict MACE in acute myocardial infarction patients, highlighting its potential clinical utility.
Abstract:
Genome-wide association studies have shown that a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS-9) is associated with the development of atherosclerosis. We assessed the level of ADAMTS-9 in patients with coronary artery disease (CAD) and its severity and prognosis. We selected 666 participants who underwent coronary angiography in our hospital and met the inclusion and exclusion criteria; participants included non-CAD patients, patients with stable angina pectoris (SAP), unstable angina, non-ST-segment elevation myocardial infarction, or ST-segment elevation myocardial infarction. The serum level of ADAMTS-9 was higher in patients with CAD than in non-CAD patients (37.53 ± 8.55 ng/mL vs 12.04 ± 7.02 ng/mL, P < .001) and was an independent predictor for CAD (odds ratio = 1.871, 95% CI: 1.533-2.283, P < .001). Subgroup analysis showed that compared with the SAP group, the acute coronary syndrome groups had higher serum levels of ADAMTS-9. In addition, the level of ADAMTS-9 was related to the SYNTAX score (r = 0.523, P < .001). Patients with acute myocardial infarction (AMI) with elevated levels of ADAMTS-9 had a higher risk of major adverse cardiovascular events (MACE) within 12 months than those with lower levels (log-rank = 4.490, P = .034). Plasma ADAMTS-9 levels may be useful for the diagnosis of CAD and as predictors of MACE in AMI patients.
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