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Challenges and opportunities in the delivery of cancer therapeutics: update on recent progress
Mathilde Lorscheider1, Alice Gaudin1, Jessica Nakhlé1
1Ipsen Innovation, 5 avenue du Canada, Z.I. Courtabœuf, Les Ulis 91190, France.
Abstract:
Global cancer prevalence has continuously increased in the last decades despite substantial progress achieved for patient care. Cancer is no longer recognized as a singular disease but as a plurality of different ones, leading to the important choice of the drug administration route and promoting the development of novel drug-delivery systems (DDS). Due to their structural diversity, therapeutic cancer drugs present specific challenges in physicochemical properties that can adversely affect their efficacy and toxicity profile. These challenges are addressed by innovative DDS to improve bioavailability, pharmacokinetics and biodistribution profiles. Here, we define the drug delivery challenges related to oral, intravenous, subcutaneous or alternative routes of administration, and review innovative DDS, marketed or in development, that answer those challenges.
Insights
Innovative drug delivery systems (DDS) are crucial for overcoming challenges with diverse cancer therapeutics. This review explores novel DDS designed to enhance drug efficacy and patient outcomes across various administration routes.
Area of Science:
- Oncology
- Pharmaceutical Sciences
- Biomedical Engineering
Background:
- Global cancer prevalence is rising, necessitating advanced treatment strategies.
- Cancer is understood as a diverse group of diseases, impacting drug choice and delivery.
- Physicochemical properties of cancer drugs pose challenges to efficacy and safety.
Purpose of the Study:
- To define drug delivery challenges for various administration routes in cancer therapy.
- To review innovative drug delivery systems (DDS) addressing these challenges.
- To highlight marketed and developmental DDS for improved cancer treatment.
Main Methods:
- Literature review of drug delivery challenges in oncology.
- Analysis of innovative drug delivery systems (DDS) for different administration routes.
- Examination of DDS impacting bioavailability, pharmacokinetics, and biodistribution.
Main Results:
- Identified specific drug delivery challenges for oral, intravenous, and subcutaneous administration.
- Reviewed a range of novel DDS, including those in development and on the market.
- Highlighted how DDS aim to improve drug efficacy and safety profiles.
Conclusions:
- Innovative drug delivery systems (DDS) are essential for modern cancer therapy.
- Addressing physicochemical challenges of cancer drugs via DDS improves therapeutic outcomes.
- Novel DDS offer promising solutions for enhancing drug delivery across multiple routes.
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