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Biologics.

Robert L Bowers1, Wesley D Troyer1, Rudolph A Mason2

  • 1Department of Physical Medicine and Rehabilitation, Emory University School of Medicine, Atlanta, GA; Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA.

Techniques in Vascular and Interventional Radiology
|December 14, 2020
PubMed
Summary
This summary is machine-generated.

Orthobiologic treatments like platelet-rich plasma (PRP) and mesenchymal stromal cells (MSCs) offer new healing potential for musculoskeletal conditions. This review covers their science, evidence, and rehabilitation for joints, tendons, ligaments, and spine injuries.

Keywords:
mesenchymal stromal cellorthobiologicsosteoarthritisplatelet-rich plasmatendinopathy

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Area of Science:

  • Orthobiologics
  • Regenerative Medicine
  • Musculoskeletal Health

Background:

  • Biologics show promise for musculoskeletal conditions in sports medicine and pain management.
  • These treatments use growth factors to stimulate the body's natural healing processes for bone and soft tissues.
  • A gap exists between conservative care and surgery for many patients with these conditions.

Purpose of the Study:

  • To review the basic science of orthobiologic treatments.
  • To summarize the evidence for using platelet-rich plasma (PRP) and mesenchymal stromal cells (MSCs).
  • To discuss post-injection rehabilitation strategies for joints, tendons, ligaments, and the spine.

Main Methods:

  • Literature review of basic science principles.
  • Systematic review of clinical evidence for PRP and MSCs.
  • Analysis of rehabilitation protocols following orthobiologic injections.

Main Results:

  • PRP and MSCs leverage the body's healing mechanisms.
  • Evidence supports their use in various musculoskeletal applications.
  • Specific rehabilitation is crucial for optimal outcomes.

Conclusions:

  • Orthobiologics represent a promising therapeutic option for musculoskeletal conditions.
  • Further research and standardized protocols are beneficial.
  • These treatments can potentially bridge the gap to operative management.