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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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A self-powered skin-patch electrochromic biosensor.

Sara Santiago-Malagón¹, Diego Río-Colín², Haniyeh Azizkhani¹

¹Universitat Autònoma de Barcelona, Bellaterra, Spain.

Biosensors & Bioelectronics

|December 14, 2020

Summary

This study presents a novel, self-powered, screen-printed wearable sensor for detecting lactate in sweat. The colorimetric device simplifies construction and eliminates the need for external detection systems.

Keywords:

Biosensors Electrochromism Lactate biosensor Self-powered devices Sweat sensing Wearables

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Area of Science:

Wearable biosensors
Electrochemistry
Screen-printing technology

Background:

Current skin-patch sensors rely on complex and costly silicon-based electronics.
Self-powered sensors combined with electrochromic materials offer a simpler, cost-effective alternative.
Eliminating external detection systems enhances the practicality of wearable analytical tools.

Purpose of the Study:

To develop a self-powered electrochromic sensor for naked-eye metabolite determination in sweat.
To create a simplified, screen-printed device for lactate detection.
To demonstrate a cost-effective and user-friendly wearable sensing solution.

Main Methods:

Screen-printing a self-powered electrochromic device.
Utilizing a lactate oxidase and osmium-polymer anode.
Employing a Prussian Blue cathode on a PEDOT:PSS electrode.
Using an ion-gel (PVDF-co-HFP and EMIM-Tf) for component separation and protection.

Main Results:

The sensor visually displays lactate concentrations (0-10 mM) as a color bar.
A contrast ratio of 1.43 was achieved for the colorimetric display.
85% of the color change is visible within 10 minutes, with full response in 24 minutes.
The transparent PEDOT:PSS electrode ensures visibility of the Prussian Blue color change.

Conclusions:

A simplified, self-powered electrochromic sensor for sweat lactate analysis has been successfully constructed.
The screen-printing method enables cost-effective fabrication of wearable biosensors.
This technology offers a promising platform for non-invasive, visual monitoring of metabolites.