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One-pot preparation of a multi-functional enzymatically generated gelatin hydrogel with controllable antibacterial
Xing Zhu1, Ting Gan2, Xuechuan Wang2
1College of Bioresources Chemical and Materials Engineering, Institute of Biomass & Functional Materials, Shaanxi University of Science & Technology, Weiyang District, Xi'an 710021, Shaanxi, China; The Youth Innovation Team of Shaanxi Universities, Xi'an 710021, Shaanxi, China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an 710021, Shaanxi, China.
Abstract:
The creation of multi-functional bio-hydrogels with tunable properties that meet in vivo demands is significant but remains challenging. Inspired by host-guest chemistry, a novel multi-functional gelatin-based bio-hydrogel with tunable antibacterial and hemorheological properties (TAH-GEL) is synthesized via an in situ one-pot strategy. TAH-GEL not only exhibits excellent mechanical properties but also shows promising self-healing and bio-compatibility features. For the first time, this biomaterial presents controllable antibacterial and hemorheological properties by controlling the TAH-GEL polypseudorotaxane motif. The resulting bio-hydrogel is easy to prepare and delivers superior performance, making it a powerful tool for bio-applications, such as hemostatic materials.
