Visual Working Memory Guides Spatial Attention: Evidence from alpha oscillations and sustained potentials

Selective attention can facilitate performance by filtering irrelevant information and temporary maintaining limited information to accomplish the current task. However, the neural substrate how attentional selection can be guided by visual working memory (vWM) is not clear. Here, we recorded electrophysiological signals during vWM retention and investigated the relationship between objects held in memorial templates and the subsequent attentional selection during visual search. We observed that sustained posterior contralateral delay activity (CDA) was present and scaled with lateral vWM loads during the whole period of vWM retention, but that it was absent when objects were bilaterally held in vWM. Surprisingly, a strikingly similar pattern emerged for modulations in the averaged posterior alpha (8-12 Hz) power during the late period but not during the early period of retention. More importantly, it was the alpha modulation, but not the CDA, that strongly predicted the subsequent biomarker of attentional selection (the memorial template-induced N2pc) during visual search. We further observed the N2pc amplitudes decreased with increasing memory loads and predicted the same gradation of the final behavioral accuracy in visual search. All these results suggested that the subsequent memorial template-induced N2pc is response to the level of top-down attentional guiding effect caused by vWM. Our results provide neurophysiological evidence that keeping multiple templates in working memory simultaneously weakens the guiding effect to the following attentional selection.