Related Experiment Video

Updated: Nov 26, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.9K

Reduction in all-cause mortality in COVID-19 patients on chronic oral anticoagulation: A population-based propensity

Gentian Denas1, Nicola Gennaro2, Eliana Ferroni2

  • 1Cardiology Clinic, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua University Hospital, Padua, Italy.

International Journal of Cardiology
|December 14, 2020
PubMed

Insights

Elderly patients with atrial fibrillation on chronic anticoagulation had lower in-hospital mortality from COVID-19 compared to similar patients not on anticoagulation. Further research is needed to confirm these findings on COVID-19 mortality risk.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Geriatrics

Background:

  • The COVID-19 pandemic is associated with a high mortality rate, partly due to hypercoagulability.
  • Understanding factors influencing COVID-19 mortality is crucial for patient management.

Purpose of the Study:

  • To compare in-hospital mortality rates between COVID-19 patients on chronic anticoagulation for atrial fibrillation and those not on anticoagulation.

Main Methods:

  • A population-based retrospective study in the Veneto Region, Italy.
  • Inclusion of elderly patients (≥65 years) with laboratory-confirmed COVID-19.
  • Propensity score matching was used to compare outcomes between anticoagulated and non-anticoagulated groups.

Main Results:

  • The study included 4697 COVID-19 patients, with 559 in each propensity score-matched cohort.
  • The all-cause mortality rate was significantly higher in non-anticoagulated patients (32.2%) compared to anticoagulated patients (26.5%, p=0.036).
  • Time-to-event analysis indicated a trend towards lower all-cause mortality in anticoagulated patients (HR 0.81, p=0.054).

Conclusions:

  • Elderly COVID-19 patients on chronic oral anticoagulation for atrial fibrillation may have a reduced risk of all-cause mortality.
  • These findings suggest a potential protective effect of anticoagulation, but require confirmation in further studies.
Abstract

Keywords:
AnticoagulationAtrial fibrillationCOVID-19DOACMortalitySurvivalVKA

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.7K
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

14.2K

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.7K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.3K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
156
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
131
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
483
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
106