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Fatty liver is an independent risk factor for gallbladder polyps
Dong-Won Ahn1, Ji Bong Jeong1, Jinwoo Kang1
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, South Korea.
Gallbladder polyps are linked to fatty liver disease, a significant finding for metabolic health. Sarcopenia and visceral obesity were not associated with gallbladder polyps in this study.
Area of Science:
- Hepatology
- Gastroenterology
- Metabolic Health
Background:
- Gallbladder polyps (GBPs) are associated with obesity and metabolic diseases.
- The relationship between GBPs and abnormal body fat distribution, including fatty liver, visceral obesity, and sarcopenia, remains unclear.
Purpose of the Study:
- To investigate the association between gallbladder polyps and fatty liver, visceral obesity, and sarcopenia.
Main Methods:
- Retrospective review of 1405 subjects with GBPs and 2810 age- and sex-matched controls.
- Data collected included laboratory tests, body composition analysis, and abdominal ultrasonography.
Main Results:
- Fatty liver was an independent risk factor for GBPs (OR 1.413).
- Fatty liver demonstrated an independent (OR 1.629) and dose-dependent (OR 2.137 for moderate to severe) relationship with large GBPs (≥ 5 mm).
- Sarcopenia and high visceral fat area were not significantly associated with GBPs.
Conclusions:
- Fatty liver is closely associated with gallbladder polyps.
- This association is independent of sarcopenia and visceral obesity.
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