Related Experiment Video
Updated: Nov 26, 2025

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Published on: March 17, 2022
Treatment of Mobile Right Heart Thrombi
Xenofon M Sakellariou1, Andreas Efstathopoulos1, Konstantinos V Stamatis1
11st Cardiology Department, School of Medicine, University of Ioannina, Ioannina. Greece.
Abstract:
Right heart thrombi are detected in approximately 4% of patients with pulmonary embolism. The associated mortality is high, but the optimal strategy remains controversial. We report a case of a large mobile right heart thrombus, complicated by embolism of the right pulmonary artery, which was successfully treated with half-dose alteplase. We briefly review the literature and discuss the therapeutic options, focusing on the advantages of thrombolysis.
Learning Points:
Mobile right heart thrombi require rapid therapeutic choices between surgical thrombectomy and thrombolysis.Half-dose alteplase may be effective, even in the presence of an extensive thrombus burden.
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