Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

129
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
129
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.3K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.3K
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

91
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
91
Disorders of Hemostasis01:24

Disorders of Hemostasis

1.6K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.6K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

4.4K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
4.4K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

7.8K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Screening of organic pollutants in mollusc and fish samples from the Portuguese coast by combining liquid and gas chromatography with high resolution mass spectrometry.

Marine pollution bulletin·2025
Same author

Neoadjuvant therapy in rectal cancer-one year follow-up results of standard versus total neoadjuvant strategies.

World journal of surgical oncology·2024
Same author

Use of Hepatitis C Virus Antibody-Positive Donors in Kidney Transplantation.

Cureus·2024
Same author

Microplastic distribution in different tissues of small pelagic fish of the Northeast Atlantic Ocean.

The Science of the total environment·2023
Same author

First evidence of microplastic ingestion in the ocean giant sunfish (Mola mola).

Marine environmental research·2023
Same author

External Validation of the Toulouse-Rangueil Predictive Model to Estimate Donor Renal Function After Living Donor Nephrectomy.

Transplant international : official journal of the European Society for Organ Transplantation·2023

Related Experiment Video

Updated: Nov 26, 2025

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.2K

Cryptogenic Stroke and Valvular Strands.

Cátia Figueiredo1, Carla Sofia Rebelo1, Joana Lemos1

  • 1Department of Internal Medicine, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.

European Journal of Case Reports in Internal Medicine
|December 14, 2020
PubMed
Summary

Lambl's excrescences, a rare cause of embolic stroke, require transesophageal echocardiography for diagnosis. Early recognition and anticoagulant therapy can prevent recurrent ischemic events and improve patient outcomes.

Keywords:
Thrombosisinferior vena cava syndromelumbar painnephroblastoma

More Related Videos

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

Published on: December 23, 2022

4.7K
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
08:22

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

15.4K

Related Experiment Videos

Last Updated: Nov 26, 2025

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.2K
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

Published on: December 23, 2022

4.7K
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
08:22

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

15.4K

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Medicine

Background:

  • Ischemic stroke classification relies on etiology, with cryptogenic stroke requiring consideration of rarer causes.
  • Lambl's excrescences, a potential cause of stroke, are often underdiagnosed as they require transesophageal echocardiography (TEE) for detection.
  • Current diagnostic protocols may delay the identification of less common stroke etiologies, leading to adverse outcomes.

Purpose of the Study:

  • To highlight Lambl's excrescences as an underdiagnosed cause of cryptogenic stroke.
  • To emphasize the importance of TEE in diagnosing structural valve abnormalities.
  • To illustrate the benefits of appropriate anticoagulation therapy in managing stroke secondary to Lambl's excrescences.

Main Methods:

  • Case report of a 63-year-old male with recurrent ischemic cerebral events.
  • Diagnosis of Lambl's excrescences via transesophageal echocardiography (TEE) of the aortic valve.
  • Modification of antiplatelet therapy to anticoagulant therapy.

Main Results:

  • Transesophageal echocardiography revealed Lambl's excrescences on the aortic valve.
  • Switching from antiplatelet to anticoagulant therapy resulted in the patient remaining asymptomatic for 3 years.
  • Early diagnosis and management prevented further vascular events.

Conclusions:

  • Lambl's excrescences are an underdiagnosed cause of embolic stroke.
  • Timely diagnosis and management of this structural valve disease are crucial to prevent severe complications.
  • Standardized protocols for cryptogenic stroke could improve the identification of rare causes and prevent recurrent events.