Related Experiment Video

Updated: Nov 26, 2025

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

310

Respiratory outcomes of "new" bronchopulmonary dysplasia in adolescents: A multicenter study

Santiago Pérez-Tarazona1, Santiago Rueda Esteban2, Maria L García-García3

  • 1Division of Neonatology, La Fe University and Polytechnic Hospital, Valencia, Spain.

Pediatric Pulmonology
|December 14, 2020
PubMed

Insights

Adolescents with "new" bronchopulmonary dysplasia (BPD) born extremely preterm show poorer lung function. This study evaluated respiratory outcomes in adolescents with BPD, highlighting potential long-term impacts.

Area of Science:

  • Pediatric Pulmonology
  • Neonatology
  • Respiratory Medicine

Background:

  • Long-term respiratory outcomes of "new" bronchopulmonary dysplasia (BPD) in preterm infants are not fully understood.
  • Bronchopulmonary dysplasia is a chronic lung disease affecting preterm infants, with evolving characteristics in the post-surfactant era.

Purpose of the Study:

  • To evaluate the respiratory outcomes in adolescents with "new" BPD born preterm.
  • To compare pulmonary function between extremely preterm (EP) adolescents with and without BPD, and moderate-late preterm adolescents.

Main Methods:

  • A multicenter, cross-sectional study of 286 adolescents born between 2003-2005.
  • Participants included extremely preterm (EP; <28 weeks) and moderate-late preterm infants, with subgroups of EP adolescents with and without BPD.
  • Lung function tests, skin prick testing, and questionnaires on asthma and quality of life were administered.

Main Results:

  • EP adolescents with BPD exhibited significantly lower FEV1, FVC, FEV1/FVC ratio, and FEF25-75% compared to other groups.
  • Higher bronchodilator response and air-trapping were observed in BPD adolescents.
  • Diffusion capacity was lower in EP adolescents compared to moderate-late preterm adolescents, but asthma symptoms and quality of life were similar across groups.

Conclusions:

  • "New" BPD in extremely preterm adolescents is associated with poorer pulmonary function.
  • Further research is necessary to determine if "new" BPD predicts adult-onset chronic obstructive pulmonary disease (COPD).
Abstract

Keywords:
asthmachronic lung diseaseprematuritypulmonary function

More Related Videos

Intratracheal Instillation of Stem Cells in Term Neonatal Rats04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

5.9K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.2K

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
2.5K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.8K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
555
Assessment of Respiration01:23

Assessment of Respiration

The respiratory system's basic structures and primary functions lay the foundation for nurses' comprehensive respiratory assessments. This assessment includes subjective and objective data to gauge the patient's respiratory health.
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like...
1.6K
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.4K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
774