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Related Experiment Video

Updated: Nov 26, 2025

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Changes in left ventricular electromechanical relations during targeted hypothermia.

Kristin Wisløff-Aase1,2, Viesturs Kerans3, Kristina Haugaa4,5

  • 1Department of Anaesthesiology, Oslo University Hospital - Rikshospitalet, Nydalen, PO Box 4950, 0424, Oslo, Norway. uxwisk@ous-hf.no.

Intensive Care Medicine Experimental
|December 14, 2020
PubMed
Summary

Targeted hypothermia prolonged both electrical and mechanical systole, making the electromechanical window positive and reducing repolarization dispersion. These findings in a porcine model suggest potential clinical implications for managing arrhythmias.

Keywords:
EchocardiographyElectromechanical relationsElectromechanical windowMyocardial functionTargeted hypothermiaVentricular arrhythmia

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Area of Science:

  • Cardiology
  • Physiology
  • Thermoregulation

Background:

  • Targeted hypothermia is used post-cardiac arrest and affects cardiac electrical and mechanical activity.
  • Ventricular arrhythmias are linked to differences between electrical and mechanical systole duration, known as the electromechanical window (EMW).
  • Hypothermia's impact on electromechanical relations, dispersion of repolarization, and mechanical dispersion remains largely unknown.

Purpose of the Study:

  • To investigate the electromechanical relations during targeted hypothermia at 33°C.
  • To determine if hypothermia alters electrical systole, mechanical systole, EMW, and dispersion parameters.
  • To test the hypothesis that hypothermia increases systolic durations without worsening EMW negativity or dispersion.

Main Methods:

  • Utilized a porcine model (n=14) to record ECG and echocardiography at 38°C and 33°C.
  • Measured electrical systole (QT interval) and mechanical systole (QRS onset to aortic valve closure) to calculate EMW.
  • Assessed dispersion of repolarization (T wave duration) and mechanical dispersion (strain echocardiography).

Main Results:

  • Electrical systole duration significantly increased during hypothermia at both spontaneous and paced heart rates.
  • Mechanical systolic duration was prolonged, outlasting electrical systole, and EMW shifted from negative to positive values.
  • Dispersion of repolarization decreased, while mechanical dispersion remained unchanged during hypothermia.

Conclusions:

  • Targeted hypothermia at 33°C prolongs electrical and mechanical systole, resulting in a positive EMW.
  • Hypothermia led to a reduction in dispersion of repolarization, with no significant change in mechanical dispersion.
  • These electromechanical alterations during hypothermia may hold clinical significance, warranting further human studies.