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Updated: Nov 26, 2025

Designing Silk-silk Protein Alloy Materials for Biomedical Applications
Published on: August 13, 2014
Protein Assembly: Defining the Strength of Protein-Protein Interactions Coupling the Theory with Experiments
Giampiero Mei1, Almerinda Di Venere2, Luisa Di Paola3
1Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy. mei@med.uniroma2.it.
Abstract:
In this paper we report a procedure to analyze protein homodimer interfaces.We approached the problem by means of a topological methodology. In particular, we analyzed the subunits interface of about 50 homodimers and we have defined a few parameters that allow to organize these proteins in six different classes. The main characteristics of each class of homodimers have been discussed also taking into account their stabilization energy, as reported in the literature from the experimental measurements. A paradigmatic example for each class has been reported and a graphical representation proposed in order to better explain the meaning of the parameters chosen.
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