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Altered metabolic function of the pulmonary microcirculation. Early detection of lung injury and possible functional
1Department of Pulmonary Disease, Cleveland Clinic Foundation, Ohio.
Critical Care Clinics
|July 1, 1986
Abstract:
The normal lung is the site of intense metabolic activity, largely associated with the endothelial cell. Depressed pulmonary metabolic function is seen in a wide variety of experimental animal models of acute lung injury, and is also demonstrated in ARDS patients. The evaluation of lung metabolic activity may prove to be a sensitive probe for the detection of the earliest phases of acute lung injury, as well as a guide to the severity of injury or response to therapy. Depressed lung metabolic function may play a role in the intrapulmonary and/or systemic pathophysiology of ARDS.