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The Relationship Between Asthma and Cardiovascular Disease: An Examination of the Framingham Offspring Study

Matias E Pollevick1, Kevin Y Xu2, Grace Mhango3

  • 1Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; Feinberg School of Medicine at Northwestern University, Chicago, IL.

Chest
|December 14, 2020
PubMed

Insights

Asthma increases the risk of developing cardiovascular disease (CVD). This longitudinal study found asthma is a significant risk factor for CVD, even after accounting for other risk factors.

Area of Science:

  • Cardiology
  • Pulmonology
  • Epidemiology

Background:

  • Limited longitudinal data exists on asthma as a cardiovascular disease (CVD) risk factor.
  • Asthma's role in CVD development requires further investigation.

Purpose of the Study:

  • To longitudinally examine the association between asthma and lifetime risk of cardiovascular disease (CVD).
  • To assess this relationship while controlling for established cardiovascular risk factors.

Main Methods:

  • Prospective cohort study of 3,612 individuals from the Framingham Offspring Cohort (1979-2014).
  • Asthma defined by physician diagnosis; incident CVD included myocardial infarction, stroke, and heart failure.
  • Time-dependent Cox regression models analyzed asthma and CVD incidence.

Main Results:

  • 15% of participants had asthma; 25% developed CVD.
  • Unadjusted analysis showed asthma associated with increased CVD incidence (HR, 1.40).
  • Adjusted analysis confirmed asthma as a risk factor for CVD (HR, 1.28) after controlling for confounders.

Conclusions:

  • Asthma is an independent risk factor for cardiovascular disease (CVD).
  • Asthma should be considered and managed as a contributing factor to CVD morbidity and mortality.
Abstract

Keywords:
Framingham Offspring Cohortasthmacardiovascular disease

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