Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Functional Brain Systems: Reticular Formation

Functional Brain Systems: Reticular Formation

The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Anti-CD19 CAR T-cell consolidation therapy combined with CD19+ feeding T cells and TKI for Ph+ acute lymphoblastic leukemia.

Blood advances·2023

Same author

Establishment of a novel system for photothermal removal of ampicillin under near-infrared irradiation: Persulfate activation, mechanism, pathways and bio-toxicology.

Journal of colloid and interface science·2023

Same author

Systematic analysis and expression of Gossypium 2ODD superfamily highlight the roles of GhLDOXs responding to alkali and other abiotic stress in cotton.

BMC plant biology·2023

Same author

Polybrominated diphenyl ethers in water, suspended particulate matter, and sediment of reservoirs and their tributaries in Shenzhen, a mega city in South China.

Environmental science and pollution research international·2023

Same author

Light plays a critical role in the accumulation of chlorogenic acid in Lonicera macranthoides Hand.-Mazz.

Plant physiology and biochemistry : PPB·2023

Same author

Molecular insights into enhanced nitrogen removal induced by trace fluoroquinolone antibiotics in an anammox system.

Bioresource technology·2023

Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026

Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026

Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026

Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026

Same journal

Neural responses to equity and inequity when receiving vicarious rewards for self and charity during adolescence.

NeuroImage·2026

Same journal

Cognitive Strategy-based neuromodulation optimizes neural communication to improve working memory.

NeuroImage·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 26, 2025

Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Spatiotemporal functional interactivity among large-scale brain networks.

Nan Xu¹, Peter C Doerschuk², Shella D Keilholz¹

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.

|December 14, 2020

Summary

This summary is machine-generated.

This study reveals how brain networks communicate over time, finding strong connections within networks like somatomotor and visual systems, and dynamic input/output patterns for key brain regions.

Keywords:

Directed functional connectivity Functional networks Information flow Resting-state fMRI Spatiotemporal functional interactivity

More Related Videos

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

Published on: June 30, 2018

Related Experiment Videos

Last Updated: Nov 26, 2025

Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

Published on: June 30, 2018

Area of Science:

Neuroscience
Cognitive Neuroscience
Functional Neuroimaging

Background:

Human brain's macro-scale functional network architecture is established.
Recent research explores temporal dynamics of large-scale brain networks.
Directed connectivity and temporal patterns of afferent/efferent connections remain understudied.

Purpose of the Study:

Investigate causal interactions within and between large-scale brain networks.
Characterize spatiotemporal dynamics of information transfer using novel methods.
Analyze directed and temporal connectivity patterns in resting-state fMRI data.

Main Methods:

Employed a novel analytic approach: prediction correlation.
Utilized resting-state functional magnetic resonance imaging (fMRI) data.
Analyzed data from the Human Connectome Project (N=200) with 4 scans per subject (TR=1200).

Main Results:

Strongest, longest duration connections found within somatomotor, visual, and dorsal attention networks.
Short duration connections observed in high-degree nodes (visual, default, hippocampus), often efferent.
Hippocampal nodes showed afferent profiles; lateral prefrontal nodes exhibited bidirectional connectivity.

Conclusions:

Novel insights into spatiotemporal dynamics of human brain function.
Prediction correlation effectively characterizes information transfer across spatial and temporal scales.
Findings highlight network-specific connectivity patterns and node roles in information processing.