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Survival in adult inpatients with COVID-19
E Murillo-Zamora1, C M Hernandez-Suarez2
1Departamento de Epidemiología, Unidad de Medicina Familiar No. 19, Instituto Mexicano del Seguro Social, Av. Javier Mina 301, Col. Centro, C.P. 28000, Colima, Colima, México; Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Col. Las Víboras, C.P. 28040, Colima, Colima, México.
Insights
Survival rates for hospitalized COVID-19 patients decline significantly within 30 days. Male gender, older age, and certain health conditions increase mortality risk, while asthma may offer protection.
Area of Science:
- Epidemiology
- Public Health
- Infectious Diseases
Background:
- The COVID-19 pandemic has a high mortality rate, with limited data on patient prognosis.
- Understanding survival trends and risk factors in hospitalized adults is crucial for managing the disease.
Purpose of the Study:
- To evaluate the survival experience of adult inpatients with laboratory-confirmed COVID-19.
- To identify factors influencing the prognosis and mortality risk in this patient population.
Main Methods:
- Nationwide retrospective cohort study involving 66,123 individuals.
- Kaplan-Meier method used for survival analysis.
- Multivariate Cox proportional hazard regression model fitted to identify risk factors.
Main Results:
- Hospitalized patients showed a 7-day survival of 72.2%, decreasing to 23.9% by day 30.
- Increased mortality risk was associated with male gender, advanced age, pneumonia, immunosuppression, and chronic non-communicable diseases.
- A history of asthma was linked to a reduced risk of fatal outcomes.
Conclusions:
- This study represents the largest analysis of COVID-19 survival probability in Latin American adults.
- Findings enhance the understanding of COVID-19 disease progression and outcomes in a high-burden population.
- Identified risk and protective factors can inform clinical management and public health strategies.
Background:
The mortality of the coronavirus disease 2019 (COVID-19) pandemic is high, and data regarding its prognosis are scarce. We aimed to assess the survival experience and determining factors in adult inpatients with laboratory-confirmed COVID-19.
Methods:
We conducted a nationwide and retrospective cohort study. Data from 66,123 individuals were analyzed using the Kaplan-Meier method, and a multivariate Cox proportional hazard regression model was fitted.
Results:
The 7-day survival was 72.2% and went to 47.6%, 35.0%, and 23.9% on days 15, 21, and 30 of hospital stay, respectively. In the multiple analysis, factors associated with an increased risk of dying were male gender, age, pneumonia at hospital admission, immunosuppression, and personal history of chronic non-communicable diseases. Reduced risk of a fatal outcome was observed among patients with asthma history.
Conclusions:
To the best of our knowledge, this is the largest study analyzing the survival probability in a large subset of Latin-American adults with COVID-19, in whom the disease burden has been high. Our results contribute to achieving a better understanding of disease evolution.
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