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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Adiponectin in Chronic Kidney Disease.

Jarosław Przybyciński1, Violetta Dziedziejko2, Kamila Puchałowicz2

  • 1Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.

International Journal of Molecular Sciences
|December 15, 2020
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Summary

Adiponectin, a protein regulating metabolism and inflammation, plays a complex role in chronic kidney disease (CKD). While beneficial in some aspects, elevated serum adiponectin correlates with mortality in CKD patients.

Keywords:
adiponectin receptorsatherosclerosisbonediabetesdialysiskidneyobesitytransplantationvasculature

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Area of Science:

  • Endocrinology
  • Nephrology
  • Metabolic Research

Background:

  • Adiponectin is an adipokine known for insulin sensitization, metabolic regulation, and anti-inflammatory effects.
  • It is found in kidney tissues and is implicated as a marker for negative factors in chronic kidney disease (CKD).
  • Emerging evidence highlights adiponectin's protective actions against oxidative stress and atherosclerosis.

Purpose of the Study:

  • To review the multifaceted role of adiponectin in the context of chronic kidney disease.
  • To explore adiponectin's direct and indirect actions on kidney cells and disease progression.

Main Methods:

  • Literature review of cross-sectional and cohort studies.
  • Analysis of existing data on adiponectin's correlation with mortality in CKD.
  • Synthesis of evidence regarding adiponectin's local and systemic effects in kidney disease.

Main Results:

  • Adiponectin exhibits protective functions in kidney diseases, including anti-inflammatory and antioxidant properties.
  • Elevated serum adiponectin levels show a positive correlation with mortality in patients with chronic kidney disease.
  • The relationship between adiponectin and CKD outcomes is complex, influenced by local actions, comorbidities, and the uremic environment.

Conclusions:

  • Adiponectin has diverse roles in chronic kidney disease, with both protective and detrimental associations.
  • Serum adiponectin levels may serve as a prognostic marker for mortality in CKD patients.
  • Further research is needed to elucidate the complex interplay of adiponectin in the pathophysiology of CKD.