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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
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Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents
Marina Porchia1, Maura Pellei2, Fabio Del Bello3
1ICMATE-C.N.R., Corso Stati Uniti 4, 35127 Padova, Italy.
Molecules (Basel, Switzerland)
|December 15, 2020
Summary
Zinc complexes offer a promising alternative to platinum-based chemotherapy due to their lower toxicity. This review highlights recent advancements in designing and synthesizing novel zinc compounds for cancer treatment.
Area of Science:
- Medicinal Inorganic Chemistry
- Cancer Therapeutics
- Drug Discovery
Background:
- Zinc is an essential trace element vital for human physiology, involved in numerous proteins and enzymes.
- Dysregulation of zinc homeostasis is linked to various diseases, including cancer.
- Zinc(II) complexes exhibit lower toxicity and fewer side effects compared to other metal-based drugs.
Purpose of the Study:
- To review the design, synthesis, and biological evaluation of zinc complexes with N-donor ligands.
- To focus on advancements in zinc-based anticancer agents reported in the last five years.
- To explore zinc derivatives as potential alternatives to platinum-based chemotherapy.
Main Methods:
- Literature review of scientific publications within the last five years.
- Analysis of the design principles for zinc coordination complexes.
- Evaluation of synthesis strategies and biological studies of N-donor zinc complexes.
Main Results:
- Numerous zinc coordination complexes with N-donor ligands have been synthesized and studied.
- These complexes show potential as anticancer agents with varying mechanisms of action.
- Recent research demonstrates the feasibility of developing effective and less toxic zinc-based antitumor drugs.
Conclusions:
- Zinc complexes represent a viable and promising class of metal-based anticancer drugs.
- Continued research into N-donor zinc complexes is crucial for developing novel cancer therapies.
- The low toxicity profile of zinc(II) complexes makes them attractive candidates for clinical application.
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