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Updated: Nov 25, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
The place of sphingosine-1-phosphate modulators in the therapy of inflammatory bowel diseases
Kamil Szymaszkiewicz1, Agata Szymaszkiewicz2, Jakub Fichna3
1Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Lodz, Lodz, Poland. kamil.szymaszkiewicz93@gmail.com.
Abstract:
Sphingosine-1-phosphate (S1P) belongs to the group of biologically active sphingolipids. Because of its ability to regulate the migration of lymphocytes, S1P constitutes an important element of pathophysiology of several diseases, such as: lupus erythematosus, multiple sclerosis or inflammatory bowel diseases. Inflammatory bowel diseases (IBD) are the group of chronic and recurrent diseases of the gastrointestinal tract. The most common among IBD are: Crohn’s disease and ulcerative colitis. Drugs that are currently used in the therapy of IBD alleviate symptoms, improve patients’ quality of life and induce remission but their efficacy is not satisfactory. Modulators of S1P receptors constitute an emerging option in the therapy of IBD. In this review we will discuss the role of S1P, its receptor and enzymes that participate in the metabolism of S1P under physiological conditions and in the course of IBD. Moreover, we will sum up the results of preclinical and clinical studies on S1P receptors modulators in IBD.
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