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Hypercoagulability and ischaemic heart disease.

T W Meade1

  • 1MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex.

Blood Reviews
|March 1, 1987
PubMed
Summary
This summary is machine-generated.

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Increased factor VII activity and plasma fibrinogen levels are linked to a higher risk of ischemic heart disease (IHD). These coagulation factors play a significant role in thrombogenesis and atheroma development, influencing IHD progression.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Epidemiology

Background:

  • Thrombogenesis is a primary cause of ischemic heart disease (IHD) and atheroma.
  • The hemostatic system significantly contributes to atheroma development.
  • Understanding hypercoagulability is crucial for IHD research.

Purpose of the Study:

  • To investigate the role of hypercoagulability in the development of IHD.
  • To examine the relationship between coagulation factors and IHD incidence.
  • To explore the pathogenetic significance of elevated factor VII activity and fibrinogen levels.

Main Methods:

  • Epidemiological studies, including the Northwick Park Heart Study (NPHS).
  • Analysis of coagulation factor levels in relation to IHD incidence.

Related Experiment Videos

  • Biochemical characterization of factor VII and its relation to thrombin production.

    • Main Results:

    • A strong association was demonstrated between factor VII activity levels and IHD incidence.
    • High levels of factor VII activity correlate with increased thrombin production.
    • Elevated plasma fibrinogen levels are also associated with increased IHD incidence in multiple prospective studies.

    Conclusions:

    • Hypercoagulability, defined as over-activity of procoagulatory influences, is implicated in IHD.
    • Factor VII activity and plasma fibrinogen are significant determinants of IHD risk.
    • Dietary fat intake influences factor VII levels, while smoking affects fibrinogen levels.