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Inhibitory control dysfunction in parkinsonian impulse control disorders.

Garance M Meyer1,2,3,4, Charlotte Spay1,2,3,4, Alina Beliakova1,2,3,4

  • 1Université de Lyon, F-69622, Lyon, France.

Brain : a Journal of Neurology
|December 15, 2020
PubMed
Summary
This summary is machine-generated.

Parkinson's disease patients with impulse control disorders (ICDs) show impaired action impulsivity. This is linked to reduced beta activity in the precuneus and supplementary motor area, indicating issues with proactive inhibitory control.

Keywords:
Parkinsonbetaimpulsivityinhibitory controlprecuneus

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Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Impulse control disorders (ICDs) in Parkinson's disease (PD) are linked to reward-based decision-making deficits.
  • The role of action impulsivity and its neural underpinnings in PD-ICDs remains unclear.

Purpose of the Study:

  • To investigate the neural mechanisms of action impulsivity in Parkinson's disease patients with and without ICDs.
  • To examine the role of inhibitory control in PD-ICDs.

Main Methods:

  • High-resolution EEG recordings were used in 41 Parkinson's disease patients (with and without ICDs).
  • A simple visuomotor task without response competition or reward was employed to assess inhibitory control.
  • Spectral and dynamical EEG signatures related to inhibitory control mechanisms were analyzed.

Main Results:

  • Patients with PD-ICDs exhibited greater behavioral impulsivity compared to those without ICDs.
  • Decreased beta activity was observed in the precuneus and medial frontal cortex (supplementary motor area) in patients with PD-ICDs.
  • EEG dynamical patterns indicated a dysfunction in proactive inhibitory control.

Conclusions:

  • Action impulsivity, specifically impaired proactive inhibitory control, plays a significant role in Parkinson's disease ICDs.
  • The precuneus and supplementary motor area are crucial for executive functions like inhibitory control in PD.
  • Findings suggest a non-dopaminergic basis for these executive dysfunctions in PD-ICDs.