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Updated: Nov 25, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

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Dissecting Clonal Heterogeneity in AML.

Jan Jacob Schuringa¹, Constanze Bonifer²

¹Department of Experimental Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, the Netherlands.

|December 15, 2020

Summary

This summary is machine-generated.

Acute myeloid leukemia is a dynamic, multi-clonal disease. Genetic mutations evolve linearly and through branching during progression and treatment, revealing a distinct mutational order.

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Comparative Lesions Analysis Through a Targeted Sequencing Approach

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Area of Science:

Hematology
Cancer Biology
Genetics

Background:

Acute myeloid leukemia (AML) is a complex hematologic malignancy.
Understanding the clonal architecture of AML is crucial for effective treatment strategies.

Purpose of the Study:

To elucidate the clonal dynamics of acute myeloid leukemia.
To characterize the evolutionary trajectories of AML during disease progression and therapy.

Main Methods:

Targeted single-cell DNA sequencing was employed.
Analysis of clonal evolution patterns in AML samples.

Main Results:

AML is confirmed as a highly dynamic, oligoclonal disease.
Clonal evolution follows both linear and branched patterns.
A defined order of mutational events was identified during disease progression and treatment.

Conclusions:

Single-cell sequencing provides critical insights into AML heterogeneity.
The identified clonal evolution patterns offer potential therapeutic targets.
Understanding mutational order may guide personalized AML treatment approaches.