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Updated: Nov 25, 2025
Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
Published on: September 13, 2022
Genome-wide translation patterns in gliomas: An integrative view
Glaucia Noeli Maroso Hajj1, Paula Borzino Cordeiro Nunes2, Martin Roffe1
1International Research Institute, A.C.Camargo Cancer Center, Rua Taguá, 440, São Paulo ZIP Code: 01508-010, Brazil; National Institute of Oncogenomics and Innovation, Brazil.
Abstract:
Gliomas are the most frequent tumors of the central nervous system (CNS) and include the highly malignant glioblastoma (GBM). Characteristically, gliomas have translational control deregulation related to overactivation of signaling pathways such as PI3K/AKT/mTORC1 and Ras/ERK1/2. Thus, mRNA translation appears to play a dominant role in glioma gene expression patterns. The, analysis of genome-wide translated transcripts, together known as the translatome, may reveal important information for understanding gene expression patterns in gliomas. This review provides a brief overview of translational control mechanisms altered in gliomas with a focus on the current knowledge related to the translatomes of glioma cells and murine glioma models. We present an integrative meta-analysis of selected glioma translatome data with the aim of identifying recurrent patterns of gene expression preferentially regulated at the level of translation and obtaining clues regarding the pathological significance of these alterations. Re-analysis of several translatome datasets was performed to compare the translatomes of glioma models with those of their non-tumor counterparts and to document glioma cell responses to radiotherapy and MNK modulation. The role of recurrently altered genes in the context of translational control and tumorigenesis are discussed.
Insights
This review explores how mRNA translation impacts glioma development. Analyzing glioma translatomes reveals key gene expression patterns and potential therapeutic targets for brain tumors.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Cancer Genomics
Background:
- Gliomas, including glioblastoma (GBM), are common central nervous system (CNS) tumors.
- Deregulation of mRNA translation, driven by pathways like PI3K/AKT/mTORC1 and Ras/ERK1/2, is characteristic of gliomas.
- Understanding translational control is crucial for deciphering glioma gene expression.
Purpose of the Study:
- To review altered translational control mechanisms in gliomas.
- To focus on the translatomes of glioma cells and murine models.
- To identify recurrent translational alterations and their pathological significance in glioma.
Main Methods:
- Overview of translational control mechanisms in gliomas.
- Analysis of existing glioma translatome datasets.
- Integrative meta-analysis of selected translatome data.
- Comparison of glioma vs. non-tumor translatomes.
- Assessment of responses to radiotherapy and MNK modulation.
Main Results:
- Identified recurrent patterns of gene expression regulated at the translational level in gliomas.
- Provided insights into the pathological significance of these translational alterations.
- Documented glioma cell responses to specific treatments.
Conclusions:
- mRNA translation plays a significant role in glioma pathogenesis.
- Translatome analysis offers valuable information for understanding glioma gene expression.
- Altered translational control represents a potential avenue for therapeutic intervention in gliomas.
