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Photocurable Polymeric Blends for Surgical Application.

Teresa Cernadas1, Marta Santos1, Sónia P Miguel2,3

  • 1CIEPQPF, Department of Chemical Engineering, University of Coimbra, P-3030 790 Coimbra, Portugal.

Materials (Basel, Switzerland)
|December 16, 2020
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Summary
This summary is machine-generated.

New photocrosslinkable bioadhesives were developed from lactic acid and polycaprolactone (PCL) oligomers. These materials show promise as flexible, resistant surgical adhesives with good biocompatibility and antibacterial properties.

Keywords:
antibacterial activitybioadhesivebiocompatibilityphotocuringpolymeric blends

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surgical Adhesives

Background:

  • Development of advanced bioadhesives is crucial for minimally invasive surgery.
  • Photocrosslinkable materials offer controlled curing and improved mechanical properties.
  • Lactic acid and polycaprolactone (PCL) are biocompatible polymers suitable for biomedical applications.

Purpose of the Study:

  • To synthesize and characterize photocrosslinkable bioadhesives from functionalized lactic acid and PCL oligomers.
  • To evaluate the thermal, mechanical, degradation, and biological properties of the developed bioadhesives.
  • To assess the potential of these materials as surgical adhesives.

Main Methods:

  • Synthesis of lactic acid-2-isocyanoethyl acrylate (LA-AOI) and PCL-2-isocyanoethyl acrylate (PCL-AOI) macromers.
  • Formulation of polymeric blends and UV-crosslinking.
  • Characterization using 1H NMR, rheology, gel content, hydrolytic degradation, and dynamic contact angle measurements.
  • Cytotoxicity evaluation with human dermal fibroblasts and antibacterial testing against E. coli and S. aureus.

Main Results:

  • Successfully synthesized and characterized LA-AOI (mLA) and PCL-AOI (mCL) macromers.
  • Developed photocrosslinkable bioadhesive blends with varying mass proportions (1:1, 1:2, 2:1).
  • Obtained flexible and resistant films with good thermal and mechanical properties after UV irradiation.
  • Demonstrated favorable hydrolytic degradation, low cytotoxicity, and notable antibacterial activity.

Conclusions:

  • Photocrosslinkable bioadhesives synthesized from functionalized lactic acid and PCL oligomers exhibit promising properties for surgical applications.
  • The developed materials offer a combination of flexibility, resistance, biocompatibility, and antibacterial effects.
  • These findings support the potential use of these novel bioadhesives in clinical settings.