Related Experiment Video

Updated: Nov 25, 2025

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

717

Evidence Limitations in Determining Sexually Dimorphic Outcomes in Pediatric Post-Traumatic Hypopituitarism and the

Alina Nico West1, Alicia M Diaz-Thomas2, Nadeem I Shafi1

  • 1Division of Critical Care Medicine, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, United States.

Frontiers in Neurology
|December 16, 2020
PubMed

Insights

Pediatric traumatic brain injury (TBI) can cause neuroendocrine dysfunction, specifically hypopituitarism. Research on sex differences in pediatric post-traumatic hypopituitarism (PTHP) is limited by small studies and methodological challenges.

Area of Science:

  • Pediatric endocrinology
  • Neurotrauma
  • Child psychology

Background:

  • Traumatic brain injury (TBI) can lead to neuroendocrine dysfunction.
  • Disruptions to the hypothalamic-pituitary axis are particularly concerning in children.
  • Pediatric post-traumatic hypopituitarism (PTHP) impacts growth and development.

Purpose of the Study:

  • To review and summarize existing literature on sex differences in pediatric PTHP.
  • To identify limitations and challenges in current research.
  • To highlight the importance of considering pubertal stage and timing of injury.

Main Methods:

  • Systematic review of current literature.
  • Analysis of studies investigating incidence, time course, and impact of PTHP.
  • Examination of methodological challenges and temporal limitations in existing research.

Main Results:

  • Current understanding of pediatric PTHP is limited by small study sizes and methodological issues.
  • Limited temporal windows in studies hinder comprehensive analysis.
  • The interplay between TBI, neuroendocrine function, and adverse childhood events requires further investigation.

Conclusions:

  • Progress in understanding sex differences in pediatric PTHP requires addressing research heterogeneity.
  • Standardized methodologies and broader temporal analyses are crucial.
  • Further research is needed to understand the complex interplay of factors influencing sexually dimorphic outcomes in pediatric TBI survivors.

Keywords:
Pediatric hypopituitarismTBIadverse childhood eventsneurocognitionneuroendocrine dysfunctionneuropsychologyneurotraumasexual dimorphism

More Related Videos

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.7K
Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats06:38

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

16.1K

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
64.3K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
90