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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
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A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
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Rutin-Loaded Silver Nanoparticles With Antithrombotic Function.

Haitao Wu1, Manlin Su1, Hui Jin1

  • 1Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, Wuxi, China.

Frontiers in Bioengineering and Biotechnology
|December 16, 2020
PubMed
Summary
This summary is machine-generated.

Rutin-loaded silver nanoparticles (Rutin@AgNPs) show enhanced stability and solubility for improved anticoagulant and antithrombotic effects. These nanoparticles effectively inhibit thrombosis with a reduced risk of bleeding, offering a promising therapeutic option.

Keywords:
anticoagulantantithrombosisrutinsilver nanoparticlessustained release

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Area of Science:

  • Biomaterials Science
  • Nanomedicine
  • Pharmacology

Background:

  • Traditional anticoagulants often face challenges with stability and bleeding risks.
  • Rutin, a natural flavonoid, possesses anticoagulant properties but suffers from poor stability and solubility.
  • Developing novel drug delivery systems can enhance the therapeutic efficacy of natural compounds.

Purpose of the Study:

  • To fabricate and characterize rutin-loaded silver nanoparticles (Rutin@AgNPs) as a nano-anticoagulant.
  • To evaluate the serum stability, anticoagulation activity, and bleeding risk of Rutin@AgNPs.
  • To assess the potential of Rutin@AgNPs for antithrombotic therapy.

Main Methods:

  • Fabrication of rutin-loaded silver nanoparticles (Rutin@AgNPs).
  • Evaluation of serum stability, hemocompatibility, and cytocompatibility.
  • Assessment of anticoagulation activity using coagulation parameter assays (aPTT, PT) in a mouse model.
  • Thrombus formation test and bleeding time evaluation in vivo.

Main Results:

  • Rutin@AgNPs exhibited good serum stability, hemocompatibility, and cytocompatibility.
  • The stability and aqueous solubility of rutin were improved, with sustained release observed.
  • Activated partial thromboplastin time (aPTT) and prothrombin time (PT) were prolonged, indicating enhanced anticoagulation.
  • Rutin@AgNPs effectively inhibited thrombosis in a mouse model over 48 hours with minimized hemorrhage risk.

Conclusions:

  • Rutin@AgNPs represent a stable and effective nano-formulation of rutin with enhanced anticoagulant and antithrombotic properties.
  • The improved pharmacokinetic profile and reduced bleeding risk make Rutin@AgNPs a promising candidate for antithrombotic therapy.
  • This study highlights the potential of nanomedicine in improving the therapeutic application of natural compounds for cardiovascular diseases.