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Postnatally acquired CMV meningitis diagnosed via BioFire FilmArray: A case report.

A Stark¹, J Peterson¹, K Weimer¹

¹Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.

Journal of Neonatal-Perinatal Medicine

|December 16, 2020

Summary

Postnatal cytomegalovirus (CMV) meningitis is rare in premature infants. The BioFire FilmArray rapidly diagnosed CMV meningitis in a very low birth weight infant, enabling faster treatment.

Keywords:

Postnatally acquired cytomegalovirus biofire filmarray meningitis prematurity

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Published on: July 24, 2016

Area of Science:

Neonatal infectious diseases
Clinical microbiology
Diagnostic technology

Background:

Postnatal cytomegalovirus (CMV) infection is common in premature infants, often acquired through breast milk.
CMV infection can manifest as meningitis, a rare but serious condition, particularly challenging to diagnose in preterm neonates.
Current diagnostic methods for meningitis are slow, leading to prolonged empiric antibiotic use.

Observation:

A very low birth weight infant presented with symptoms suggestive of meningitis.
The infant had postnatally acquired cytomegalovirus (CMV) infection.
Diagnosis was challenging due to the infant's preterm status and rarity of CMV meningitis.

Findings:

The BioFire FilmArray (BFA), a multiplex PCR panel, was utilized for rapid pathogen detection.
BFA identified cytomegalovirus (CMV) in the cerebrospinal fluid (CSF).
This enabled a swift diagnosis of CMV meningitis, confirmed as the first such case diagnosed via BFA.

Implications:

The BioFire FilmArray offers a significant advantage in the rapid diagnosis of CNS infections in neonates.
Quicker diagnosis of CMV meningitis can lead to earlier targeted treatment, potentially improving outcomes.
This case highlights the utility of advanced molecular diagnostic tools in managing rare neonatal infections.