Related Experiment Video
Updated: Jul 24, 2026

Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier
Published on: November 13, 2013
Current aspects of the development of the blood-brain barrier
1Laboratory of Molecular Neurobiology, Institute of Biophysics, Szeged, Hungary.
Abstract:
Results of earlier studies clearly indicated that, during development, a number of enzymes are sequentially expressed in the brain endothelial cells correlating in time with the maturation of brain tissue. More recent data suggested that differentiation of endothelium in the intraparenchymal cerebral microvessels into one with blood-brain barrier characteristics seems to be induced by astrocytes at a specific time of embryonic development. Details of the above-mentioned and other important aspects of the development of the blood-brain barrier will be discussed in the present mini review.
Related Concept Videos
The Blood-brain Barrier
Physiological Barriers
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Factors Affecting Drug Distribution: Physiological Barriers
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
Cerebral Edema ll: Pathophysiology

