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3D-Bioprinted Inflammation Modulating Polymer Scaffolds for Soft Tissue Repair.

Crystal S Shin1, Fernando J Cabrera1, Richard Lee1

  • 1Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, 77030, USA.

Advanced Materials (Deerfield Beach, Fla.)
|December 16, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a novel polymer scaffold that modulates inflammation for soft tissue repair. The biomaterial scaffold effectively reduces inflammation and prevents adhesions, minimizing postsurgical complications.

Keywords:
3D-bioprintingbioscaffoldsherniainflammationsoft tissue repair

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Surgical Innovation

Background:

  • Current soft tissue repair meshes cause inflammation, leading to visceral adhesions and complications.
  • A need exists for advanced biomaterials that modulate the inflammatory response during soft tissue repair.

Purpose of the Study:

  • To develop and evaluate an inflammation-modulating biomaterial scaffold for soft tissue repair.
  • To minimize postsurgical complications such as visceral adhesions.

Main Methods:

  • Fabrication of a biomaterial scaffold using 3D-bioprinting of in situ phosphate crosslinked poly(vinyl alcohol).
  • In vivo evaluation in a rat ventral hernia model.
  • Analysis of proinflammatory cytokine expression and histopathology.

Main Results:

  • The biomaterial scaffold effectively sequestered proinflammatory cytokines, acting as an 'inflammation trap'.
  • Local inflammation was modulated without exogenous anti-inflammatory agents.
  • Significant inhibition of visceral adhesions and reduction in postsurgical complications were observed.

Conclusions:

  • The developed biomaterial scaffold successfully modulates inflammation and reduces postsurgical complications in soft tissue repair.
  • This novel scaffold offers a promising alternative to current meshes, improving hernia repair outcomes.