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Optogenetics: The Art of Illuminating Complex Signaling Pathways
Mark Shaaya1, Jordan Fauser1, Andrei V Karginov1,2
1Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, Illinois.
Physiology (Bethesda, Md.)
|December 16, 2020
Abstract:
Dissection of cell signaling requires tools that can mimic spatiotemporal dynamics of individual pathways in living cells. Optogenetic methods enable manipulation of signaling processes with precise timing and local control. In this review, we describe recent optogenetic approaches for regulation of cell signaling, highlight their advantages and limitations, and discuss examples of their application.
