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Updated: Nov 25, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Recent advances in the synthesis of α-amino ketones
Lewis A T Allen1, Robert-Cristian Raclea2, Philipp Natho1
1Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, W12 0BZ, London, UK. p.parsons@imperial.ac.uk.
Abstract:
Due to the importance of the amino ketone motif in synthetic and medicinal chemistry, the number of protocols developed in recent years has considerably increased. This review serves to collate and critically evaluate novel methodologies published since 2011 towards this high value synthon. The chapters are divided by the requisite functionality in the starting material, and an emphasis is placed on discussing functional group compatibility and resultant product substitution patterns. Throughout, applications to medicinal targets are highlighted and mechanistic details are presented, and we further provide a short outlook for future development and emerging potential within this area.
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