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AnnoLnc: A One-Stop Portal to Systematically Annotate Novel Human Long Noncoding RNAs
De-Chang Yang1,2, Lan Ke1,2, Yang Ding1,2
1Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), Center for Bioinformatics (CBI), Peking University, Beijing, China.
Methods in Molecular Biology (Clifton, N.J.)
|December 16, 2020
Summary
AnnoLnc is a comprehensive online portal for annotating human long noncoding RNAs (lncRNAs). It provides systematic annotation of lncRNA functions and regulation using over 700 data sources.
Area of Science:
- Genomics
- Bioinformatics
- Molecular Biology
Background:
- Over 100,000 long noncoding RNAs (lncRNAs) are identified in the human genome.
- The biological functions and regulatory mechanisms of most lncRNAs remain largely unknown.
Purpose of the Study:
- To present AnnoLnc, a comprehensive online annotation portal for human lncRNAs.
- To provide on-the-fly annotation for novel human lncRNAs using extensive data sources.
Main Methods:
- Development of AnnoLnc, a web server and API for lncRNA annotation.
- Integration of over 700 data sources for systematic lncRNA analysis.
- Annotation includes genomic location, secondary structure, expression, coexpression, regulation, interactions, and evolution.
Main Results:
- AnnoLnc offers a user-friendly web interface and integrates with existing pipelines via web service APIs or a stand-alone version.
- It systematically annotates inputted lncRNAs across multiple biological dimensions.
- Provides comprehensive functional and regulatory insights for novel lncRNAs.
Conclusions:
- AnnoLnc serves as a valuable resource for researchers studying human lncRNAs.
- Facilitates the exploration of lncRNA functions, regulation, and biological roles.
- Enhances the understanding of the lncRNA landscape in the human genome.
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