Related Experiment Video
Updated: Nov 25, 2025

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Occupational allergic contact urticaria to tropomyosin from squid
Daniel Wilfinger1, Annette Kuehn2, Szandra Takacs1
1Department of Occupational Diseases and Occupational Medicine, AUVA Rehabilitation Clinic Tobelbad, Tobelbad, Austria.
Abstract:
A cook's mate working in an Austrian restaurant reported acutely occurring urticarial skin lesions after processing and cooking squid. The prick-to-prick test with squid showed a ++ positive urticarial reaction. Elevated specific IgE antibody levels to squid, shrimp, and house dust mites as well as to tropomyosin from shrimp and house dust mite could be detected in the ImmunoCAP. By means of immunoblot and ELISA, a reaction to squid extract as well as increased IgE antibody levels to squid and tropomyosin from squid could be detected. The patient was diagnosed with a clinically and occupationally relevant type I allergy to squid with cross-reaction to tropomyosin of other invertebrates and therefore recognized as an occupational disease.
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