Related Experiment Videos
Leucocyte locomotion: behavioural mechanisms for accumulation
1Bacteriology and Immunology Department, University of Glasgow, Western Infirmary, UK.
Journal of Cell Science. Supplement
|January 1, 1987
Summary
Leukocyte accumulation in tissues involves both chemotaxis and non-chemotactic mechanisms. Lymphocytes gain motility via activators, while adhesive trapping and contact guidance also influence leukocyte migration and inflammatory site accumulation.
Area of Science:
- Immunology
- Cell Biology
- Biophysics
Background:
- Leukocyte accumulation is crucial for inflammatory responses.
- Neutrophils and monocytes are motile, but lymphocytes typically are not.
- Understanding leukocyte migration mechanisms is key to controlling inflammation.
Purpose of the Study:
- To review behavioral mechanisms of leukocyte accumulation.
- To discuss chemotactic and non-chemotactic factors influencing leukocyte migration.
- To explore how lymphocytes acquire motility and respond to gradients.
Main Methods:
- Literature review of studies on leukocyte behavior and migration.
- Analysis of mechanisms like chemotaxis, cell cycle, and adhesion.
- Examination of contact guidance in connective tissues.
Main Results:
- Neutrophils and monocytes exhibit efficient chemotaxis.
- Lymphocytes can be induced to become motile by growth activators (e.g., anti-CD3 antibodies).
- Adhesive trapping and contact guidance are identified as non-chemotactic accumulation mechanisms.
Conclusions:
- Leukocyte accumulation is a complex process involving multiple behavioral mechanisms.
- Both chemotactic gradients and non-chemotactic factors like adhesion and tissue structure influence leukocyte distribution.
- Further research into these mechanisms can inform therapeutic strategies for inflammatory diseases.