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Updated: Nov 25, 2025

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound
Rasmus Offersen1, Wen-Han Yu2, Eileen P Scully3
1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Infectious Diseases, Aarhus University Hospital, Aarhus 8000, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus 8000, Denmark.
Abstract:
Changes in antibody glycosylation are linked to inflammation across several diseases. Alterations in bulk antibody galactosylation can predict rheumatic flares, act as a sensor for immune activation, predict gastric cancer relapse, track with biological age, shift with vaccination, change with HIV reservoir size on therapy, and decrease in HIV and HCV infections. However, whether changes in antibody Fc biology also track with reservoir rebound time remains unclear. The identification of a biomarker that could forecast viral rebound time could significantly accelerate the downselection and iterative improvement of promising HIV viral eradication strategies. Using a comprehensive antibody Fc-profiling approach, the level of HIV-specific antibody Fc N-galactosylation is significantly associated with time to rebound after treatment discontinuation across three independent cohorts. Thus virus-specific antibody glycosylation may represent a promising, simply measured marker to track reservoir reactivation.
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