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[Pulmonary ventilation function parameters of children aged 5-14 years in Kunming, China: a comparative analysis of

Jie Yang1, Hong-Min Fu1, Tao-Zhen Bai

  • 1Department of Respiratory and Critical Diseases, Children's Hospital of Kunming Medical University, Kunming 650032, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|December 17, 2020
PubMed

Insights

This study found differences between measured and predicted pulmonary ventilation function in healthy children in Kunming. New lower limits for key parameters like forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were established for accurate clinical assessment.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Public Health

Background:

  • Pulmonary ventilation function assessment is crucial for diagnosing respiratory conditions in children.
  • Existing prediction equations, like the Zapletal equation, may not accurately reflect local pediatric populations.
  • Establishing region-specific reference values is vital for precise clinical interpretation.

Purpose of the Study:

  • To determine the percentage of measured pulmonary ventilation function parameters against Zapletal equation predicted values in healthy Kunming children (aged 5-14).
  • To provide a basis for accurate clinical judgment of pulmonary ventilation function in this specific pediatric group.
  • To identify potential discrepancies between standard predictions and observed values in the studied population.

Main Methods:

  • A cohort of 702 healthy children (5-14 years) in Kunming was studied.
  • Nine pulmonary function indices were measured using a Jaeger spirometer, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF).
  • Measured values were compared to predicted values from the Zapletal equation, calculating the percentage of measured values relative to predicted values.

Main Results:

  • Percentages of measured to predicted values varied across parameters: PEF (102-114%), FVC (94-108%), FEV1 (98-113%), FEV1/FVC (98-107%), MVV (141-183%), FEF25 (98-116%), FEF50 (85-102%), FEF75 (71-98%), and MMEF (83-100%).
  • Lower limits of normal were established: PEF (88.2%), FVC (88.4%), FEV1 (92.0%), FEV1/FVC (94.4%), MVV (118.5%), FEF25 (82.9%), FEF50 (70.0%), FEF75 (62.1%), and MMEF (70.1%).
  • Significant deviations were observed for certain parameters, particularly maximal voluntary ventilation (MVV) and maximal mid-expiratory flow (MMEF).

Conclusions:

  • Pulmonary ventilation function parameters in healthy Kunming children (5-14 years) differ from those predicted by the Zapletal equation.
  • The established lower limits of normal for measured values in predicted values provide a more accurate reference for this population.
  • These findings support the need for localized reference values in pediatric pulmonary function testing for improved diagnostic accuracy.
Abstract

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