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Modeled Reductions in Late-stage Cancer with a Multi-Cancer Early Detection Test
Earl Hubbell1, Christina A Clarke2, Alexander M Aravanis2,3
1GRAIL, Inc., Menlo Park, California. ehubbell@grailbio.com.
Background:
Cancer is the second leading cause of death globally, with many cases detected at a late stage when prognosis is poor. New technologies enabling multi-cancer early detection (MCED) may make "universal cancer screening" possible. We extend single-cancer models to understand the potential public health effects of adding a MCED test to usual care.
Methods:
We obtained data on stage-specific incidence and survival of all invasive cancers diagnosed in persons aged 50-79 between 2006 and 2015 from the US Surveillance, Epidemiology, and End Results (SEER) program, and combined this with published performance of a MCED test in a state transition model (interception model) to predict diagnostic yield, stage shift, and potential mortality reductions. We model long-term (incident) performance, accou.
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