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Corticosteroid therapy for severe COVID-19 pneumonia: optimal dose and duration of administration

Wataru Matsuda1, Tatsuya Okamoto2, Tatsuki Uemura1

  • 1Department of Emergency Medicine and Critical Care, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.

Global Health & Medicine
|December 17, 2020
PubMed

Insights

Corticosteroid therapy can help manage severe COVID-19 inflammation. Dosing and duration vary by severity, requiring careful monitoring for potential complications.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Pharmacology

Background:

  • Severe COVID-19 presents a hyperinflammatory state.
  • Corticosteroid therapy is a potential treatment option.

Purpose of the Study:

  • To review current literature on corticosteroid therapy for severe COVID-19.
  • To discuss optimal dosing and duration of corticosteroid use.

Main Methods:

  • Literature review of recent studies on COVID-19 and corticosteroid treatment.
  • Analysis of various corticosteroid doses (methylprednisolone/prednisolone) and administration durations.

Main Results:

  • Low-dose corticosteroid therapy is commonly used.
  • Doses range from 40 mg/day to 2 mg/kg/day, adjusted for severity.
  • Short-term administration is typical, but longer use may be needed for prolonged respiratory failure.

Conclusions:

  • Corticosteroid therapy is a viable option for severe COVID-19.
  • Dosing and duration require careful consideration based on individual patient needs and disease progression.
  • Vigilant monitoring for corticosteroid-related complications is essential.
Keywords:
COVID-19SARS-CoV-2acute respiratory distress syndromecomplicationscorticosteroid therapyviral RNA clearance

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