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Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung
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Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung

Published on: June 5, 2012

[Treatment of bronchitis with cefaclor (Panoral) (author's transl)]

W Kersten, W Brade

    MMW, Munchener Medizinische Wochenschrift
    |February 16, 1979
    PubMed

    Insights

    Cefaclor effectively treated acute bronchitis and chronic bronchitis exacerbations in outpatients. Most patients experienced symptom resolution and pathogen clearance after a 5-day cefaclor course.

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Respiratory Medicine

    Background:

    • Antibiotic resistance is a growing concern in respiratory infections.
    • Bacterial bronchitis and chronic bronchitis exacerbations require effective treatment options.

    Purpose of the Study:

    • To evaluate the efficacy of cefaclor in treating acute bronchitis and acute exacerbations of chronic bronchitis.
    • To assess the susceptibility of common respiratory pathogens to cefaclor and other antibiotics.

    Main Methods:

    • A clinical study involving 27 outpatients (14 with chronic bronchitis, 13 with acute bronchitis).
    • Patients received cefaclor 250 mg orally three times daily for 5 days.
    • Sputum samples were analyzed for bacterial pathogens and their antibiotic susceptibility.

    Main Results:

    • Cefaclor demonstrated high efficacy, with 12/14 chronic bronchitis patients and 12/13 acute bronchitis patients becoming asymptomatic.
    • Pathogen eradication was observed in 13/14 chronic bronchitis patients and 11/13 acute bronchitis patients post-treatment.
    • Isolated organisms showed significant resistance to tetracycline (59%), penicillin (53%), and ampicillin (37%), highlighting cefaclor's utility.

    Conclusions:

    • Cefaclor is an effective treatment for acute bronchitis and acute exacerbations of chronic bronchitis.
    • The study underscores the prevalence of resistance to older antibiotics, supporting cefaclor's role in empirical therapy.
    • Cefaclor offers a viable therapeutic option for respiratory tract infections where resistance to other common antibiotics is prevalent.

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