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Updated: Nov 25, 2025
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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
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Flow-mediated outward arterial remodeling in aging.
Ahmad Chehaitly1, Emilie Vessieres1, Anne-Laure Guihot1
1MITOVASC Laboratory and CARFI Facility, INSERM U1083, CNRS UMR 6015, University of Angers, Angers, France.
Mechanisms of Ageing and Development
|December 17, 2020
Summary
Aging impairs vascular adaptation, flow-mediated outward remodeling (FMR), due to increased inflammation and oxidative stress. Estrogen may offer therapeutic potential, but prevention remains key.
Area of Science:
- Vascular Biology
- Aging Research
- Cardiovascular Physiology
Background:
- Vascular remodeling is crucial for recovery from ischemic disorders.
- Flow-mediated outward remodeling (FMR) plays a key role in revascularization.
- FMR involves endothelial cells, smooth muscle cells, and the immune system.
Purpose of the Study:
- To review the impact of aging on flow-mediated outward remodeling (FMR).
- To explore the roles of estrogen metabolism, oxidative stress, and inflammation in age-related FMR decline.
- To identify potential therapeutic strategies for enhancing FMR in older individuals.
Main Methods:
- Review of existing literature on aging, vascular remodeling, and related molecular pathways.
- Analysis of the contribution of oxidative stress and inflammation to FMR alterations.
- Examination of the role of estrogen and its receptors in modulating vascular function.
Main Results:
- FMR capacity diminishes with age, exacerbated by inflammation and oxidative stress, often of mitochondrial origin.
- Older individuals with risk factors exhibit greater FMR impairment.
- FMR decline is delayed in females, highlighting a potential sex-specific effect.
Conclusions:
- Aging significantly reduces FMR, impacting vascular recovery.
- Estrogen and its alpha receptor (ERα) show potential for activating FMR, but data is primarily experimental.
- Preventing risk factor exposure and limiting vascular damage are currently the most effective strategies.
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