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Published on: November 29, 2024
Vascular Endothelial Growth Factor-A Is Associated with Platelets and Complement 4 in Patients with Primary Sjögren's
Zi-Yan Huang1, Yi-Ru Yuan1, Yue-Le Kong2
1School of Public Health, Xiamen University, Xiamen.
Objective:
We aimed at investigating the expression level of vascular endothelial growth factor-A (VEGF-A) in patients with primary Sjögren's Syndrome (pSS) and evaluating the relationship between serum VEGF-A and the laboratory indicators that are associated with it in pSS.
Methods:
The VEGF-A levels were measured by ELISA in a total of 88 participants, including 58 patients with pSS and 30 healthy people. The VEGF-A levels between two groups were analyzed.
Results:
The serum levels of VEGF-A in pSS and control groups were 175.50 (112.00,296.50) pg/mL and 181.50 (155.25,288.50) pg/mL, without statistically significant difference. The associations were found between serum levels of VEGF-A with C reactive protein (CRP) (r=0.265, P<0.05), white blood cells (WBC) (r=0.302, P<0.05), neutrophils (NEUT) (r=0.349, P<0.05), platelets(PLT) (r=0.276, P<0.05), complement 3 (C3) (r=0.477, P<0.05), complement 4 (C4) (r=0.387, P<0.05) and CA19-9 (r=0.392, P<0.05). Among these laboratory indicators, VEGF-A was correlated with platelets and complement 4 in patients with pSS.
Conclusions:
In patients with pSS, the levels of VEGF-A were independently influenced by the levels of platelet and complement 4, which indicated the intermodulation between the growth factor and immune system in the autoimmune disease.
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