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Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
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The Correlation Between Migraine and Patent Foramen Ovale
Kaiming Liu1, Brian Z Wang2, Yishu Hao3
1Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Frontiers in Neurology
|December 18, 2020
Summary
Migraine is more common in patients with a patent foramen ovale (PFO), a heart condition. While evidence suggests a link, further research is needed to confirm causality and optimize PFO closure treatments for migraine relief.
Area of Science:
- Neurology
- Cardiology
- Medical Research
Background:
- Migraine is a prevalent neurological disorder affecting many individuals worldwide.
- Patent foramen ovale (PFO) is a common cardiac anomaly, a remnant of fetal circulation.
- A higher prevalence of PFO in migraineurs and vice versa suggests a potential association.
Purpose of the Study:
- To investigate the relationship between PFO and migraine.
- To explore the efficacy of percutaneous PFO closure for migraine treatment.
- To clarify the potential causal link versus mere coexistence of PFO and migraine.
Main Methods:
- Systematic review of studies on PFO and migraine.
- Analysis of pathophysiological mechanisms linking PFO and migraine.
- Evaluation of clinical data on PFO closure interventions for migraine.
Main Results:
- Summarized potential pathophysiological links between PFO and migraine.
- Detailed migraine characteristics (type, frequency, symptoms) in patients with PFO.
- Addressed the impact of PFO closure on migraine frequency and severity.
Conclusions:
- Evidence suggests a dose-response relationship between migraine and PFO.
- Further research requires refined patient selection criteria for PFO closure.
- Clinical trials should include antiplatelet control groups to validate PFO closure benefits for migraine.
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