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Ultra-strong thermoresponsive double network hydrogels.

Ruochong Fei1, Jason T George1, Jeehyun Park1

  • 1Department of Biomedical Engineering, Materials Science & Engineering Program, Texas A&M University, 3120 TAMU, College Station, TX, USA.

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|December 18, 2020
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Summary

This study introduces robust double network hydrogels using poly(N-isopropylacrylamide) (PNIPAAm) and AMPS. The novel hydrogels exhibit enhanced mechanical strength and tunable thermosensitivity for advanced applications.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Biomedical Engineering

Background:

  • Thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels are promising smart materials.
  • Their application is limited by poor mechanical strength.

Purpose of the Study:

  • To enhance the mechanical properties of PNIPAAm hydrogels.
  • To investigate the effect of incorporating an electrostatic co-monomer, AMPS, into a double network (DN) hydrogel structure.
  • To evaluate the impact of AMPS content on hydrogel properties.

Main Methods:

  • Preparation of P(NIPAAm-co-AMPS)/PNIPAAm DN hydrogels with asymmetric crosslinking.
  • Sequential formation of a tightly crosslinked first network (variable NIPAAm:AMPS ratios) and a loosely crosslinked second network (PNIPAAm).
  • Evaluation of volume phase transition temperature (VPTT), morphology, kinetics, and mechanical properties.

Main Results:

  • DN hydrogels maintained PNIPAAm's VPTT while improving thermosensitivity.
  • The hydrogel with a 25:75 wt% NIPAAm:AMPS ratio demonstrated exceptional strength.
  • High modulus and high %strain at break were achieved in the optimized DN hydrogel.

Conclusions:

  • Asymmetric crosslinking and AMPS incorporation significantly enhance PNIPAAm hydrogel mechanical properties.
  • The developed DN hydrogels offer a promising platform for advanced biomedical applications requiring both responsiveness and durability.