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Updated: Nov 25, 2025

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Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2

Emily Parsons1, Matthew Timlin1, Clarise Starr2

  • 1Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA.

Journal of the Pediatric Infectious Diseases Society
|December 18, 2020
PubMed

Insights

The earliest reported case of Multisystem Inflammatory Syndrome in Children (MIS-C) occurred in February 2020, linked to an emerging SARS-CoV-2 variant. This finding highlights the early emergence of MIS-C alongside a predominant viral lineage.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Virology

Background:

  • Multisystem Inflammatory Syndrome in Children (MIS-C) is a serious condition complicating SARS-CoV-2 infection.
  • The emergence of MIS-C has been observed in conjunction with the COVID-19 pandemic.

Keywords:
COVID-19D614GMIS-CSARS-CoV-2pseudotumor cerebri syndromeviral lineage

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