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Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
Published on: July 16, 2021
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Reciprocal interactions between mesenchymal stem cells and macrophages
Małgorzata Kloc1, Ahmed Uosef, Monika Leśniak
1Houston Methodist Research Institute, Houston, TX, USA.
The International Journal of Developmental Biology
|December 18, 2020
Abstract:
Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.
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