Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

884
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
884
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.6K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.6K
Cancer Vaccines01:30

Cancer Vaccines

658
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
658
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.3K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The peripheral immune landscape of human breast cancer.

Oncoimmunology·2026
Same author

Breaking news from ESMO 2025: liquid biopsy novelties in gastrointestinal cancer.

The journal of liquid biopsy·2026
Same author

The immunology of human breast cancer.

Nature reviews. Immunology·2026
Same author

Attachment ability and mating behaviour of the black soldier fly Hermetia illucens (Diptera: Stratiomyidae).

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2026
Same author

CD44+ and CD133+ Extracellular Vesicles as Future Potential Targets in Gastrointestinal Tumor.

Frontiers in bioscience (Landmark edition)·2026
Same author

Diagnostic pitfalls and forensic implications of hyperactive delirium with severe agitation: an Italian case series.

Legal medicine (Tokyo, Japan)·2026
Same journal

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.

Cancer cell·2026
Same journal

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption.

Cancer cell·2026
Same journal

Intratumoral B cells under stress.

Cancer cell·2026
Same journal

Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth.

Cancer cell·2026
Same journal

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.

Cancer cell·2026
Same journal

OpenIO: An open framework for AI-native immunotherapy.

Cancer cell·2026
See all related articles

Related Experiment Video

Updated: Nov 25, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

1.1K

Immunomodulation by targeted anticancer agents.

Giulia Petroni1, Aitziber Buqué1, Laurence Zitvogel2

  • 1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Cancer Cell
|December 18, 2020
PubMed
Summary
This summary is machine-generated.

Targeted anticancer agents, while specific, can also affect the immune system. Understanding these immunostimulatory or immunosuppressive effects may improve cancer treatment efficacy.

Keywords:
BRAFCD8(+) cytotoxic T lymphocytesCDK4/CDK6CGAS signalingDNA damage responseEGFRKRAST(REG) cellsTGF-βimmune checkpoint blockersimmunogenic cell death

More Related Videos

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.5K
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

9.9K

Related Experiment Videos

Last Updated: Nov 25, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

1.1K
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.5K
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

9.9K

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Conventional chemotherapy lacks specificity.
  • Targeted anticancer agents inhibit specific molecular alterations driving cancer.
  • These agents can also modulate immune responses, impacting treatment outcomes.

Purpose of the Study:

  • To discuss the immunomodulatory effects of targeted anticancer agents.
  • To explore strategies for leveraging these effects to enhance clinical efficacy.

Main Methods:

  • Review of existing literature on targeted anticancer agents and their immunological impacts.
  • Analysis of immunostimulatory and immunosuppressive mechanisms.

Main Results:

  • Targeted agents exhibit diverse immunomodulatory effects.
  • These effects can be either beneficial or detrimental to therapeutic outcomes.
  • Specific examples of agents and their immune interactions are discussed.

Conclusions:

  • The immune effects of targeted anticancer agents are significant.
  • Harnessing these immunomodulatory properties offers a promising strategy for improving cancer therapy.