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Updated: Nov 25, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
[Frailty and kidney transplant candidates]
María José Pérez-Sáez1, Álex Gutiérrez-Dalmau2, Francesc Moreso3
1Servicio de Nefrología, Hospital del Mar, Barcelona, España.
Frailty, a condition of increased vulnerability, affects many chronic kidney disease patients, particularly those awaiting kidney transplants. Identifying and intervening in frailty can improve transplant outcomes and reduce complications.
Area of Science:
- Geriatrics
- Nephrology
- Transplantation Medicine
Background:
- Frailty is a geriatric concept identifying individuals at high risk for adverse outcomes following stressful events.
- Frail patients, irrespective of age or comorbidities, face elevated risks of mortality, poor prognosis, and disability.
- Chronic kidney disease (CKD) patients, especially those on renal replacement therapy, exhibit a high prevalence of frailty.
Purpose of the Study:
- To highlight the prevalence of frailty in kidney transplant candidates.
- To emphasize the association between frailty and poorer post-transplant outcomes.
- To underscore the importance of frailty assessment tools for optimizing clinical practice and patient selection.
Main Methods:
- Review of frailty assessment tools in the context of chronic kidney disease.
- Focus on the Fried frailty scale, a common tool in nephrology.
- Discussion of prehabilitation strategies for frail patients awaiting kidney transplantation.
Main Results:
- 20-30% of patients on the kidney transplant waiting list are identified as frail or pre-frail.
- Frailty is independently linked to worse outcomes after kidney transplantation.
- Frailty assessment can identify patients at risk for post-transplant complications.
Conclusions:
- Frailty assessment tools are crucial for identifying at-risk kidney transplant candidates.
- Interventions like prehabilitation may improve outcomes for frail patients.
- Further research is needed to develop and implement effective frailty management strategies in CKD patients.
Related Concept Videos
Kidney Transplant I: Introduction
Kidney Transplant II: Surgical Procedure
Kidney Transplant III: Nursing Management
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Chronic Kidney Disease I: Introduction

